Hyaluronidase in ophthalmology is most frequently used in combination with anesthetics for ophthalmologic surgery ( eg, retrobulbar block, peribulbar block, sub-Tenon’s block, and van Lint block). The rationale for the inclusion of hyaluronidase in combination with local anesthesia techniques includes smaller increases in intraocular pressure (IOP), less distortion of the surgical site, decreased incidence of postoperative strabismus, and the potential for limiting local anesthetic myotoxicity because of quicker spread. In some studies, the inclusion of hyaluronidase increases globe and lid akinesia, which may improve the safety of the procedure.
Bovine hyaluronidase also has been investigated for the clearance of vitreous hemorrhage, where its efficacy and safety have not been established. Two phase 3 clinical trials demonstrated that a single intravitreous injection of ovine hyaluronidase was not associated with any serious safety issues and hyaluronidase had some therapeutic utility in the management of vitreous hemorrhage.
More facts about hyaluronidase can be found in our information concerning Amphadase Injection for Ophthalmology
WA-007 Rev 01/2018